NTRK3
Entrez ID: 4916
Full name: neurotrophic receptor tyrosine kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Trk
Chromosomal location: 15q25.3
Substructure location: Gatekeeper: 617 A-loop: 696...711, 726...735 G-loop: 544...550 αC-helix: 579...594
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NTRK3
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival a...
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
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GO - Biological processes (BP):
activation of GTPase activity, activation of MAPK activity, activation of protein kinase B activity, cellular response to nerve growth factor stimulus, cellular response to retinoic acid, circadian rhythm, cochlea development, heart development, lens fiber cell differentiation, mechanoreceptor diffe...
activation of GTPase activity, activation of MAPK activity, activation of protein kinase B activity, cellular response to nerve growth factor stimulus, cellular response to retinoic acid, circadian rhythm, cochlea development, heart development, lens fiber cell differentiation, mechanoreceptor differentiation, modulation by virus of host transcription, multicellular organism development, myelination in peripheral nervous system, negative regulation of astrocyte differentiation, negative regulation of cell death, negative regulation of protein phosphorylation, nervous system development, neuronal action potential propagation, neuron fate specification, neuron migration, positive regulation of actin cytoskeleton reorganization, positive regulation of apoptotic process, positive regulation of axon extension involved in regeneration, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of neuron projection development, positive regulation of neurotrophin TRK receptor signaling pathway, positive regulation of peptidyl-serine phosphorylation, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of phospholipase C activity, positive regulation of positive chemotaxis, positive regulation of protein phosphorylation, positive regulation of synapse assembly, regulation of MAPK cascade, regulation of postsynaptic density assembly, regulation of presynapse assembly, regulation of protein kinase B signaling, response to axon injury, response to corticosterone, response to ethanol, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, GPI-linked ephrin receptor activity, neurotrophin binding, neurotrophin receptor activity, p53 binding, transmembrane receptor protein tyrosine kinase activity...
ATP binding, GPI-linked ephrin receptor activity, neurotrophin binding, neurotrophin receptor activity, p53 binding, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
integral component of plasma membrane, integral component of postsynaptic membrane, plasma membrane, axon, cytoplasm, glutamatergic synapse, receptor complex...
integral component of plasma membrane, integral component of postsynaptic membrane, plasma membrane, axon, cytoplasm, glutamatergic synapse, receptor complex
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neurotrophic receptor tyrosine kinase 3
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Kaplan plot for NTRK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc