PKN1
Entrez ID: 5585
Full name: protein kinase N1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: PKN
Chromosomal location: 19p13.12
Substructure location: Gatekeeper: 695 A-loop: 757...780 G-loop: 622...629 αC-helix: 648...653
Please click HERE
for better display.
PKN1
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic recept...
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.
View more >>
GO - Biological processes (BP):
activation of JUN kinase activity, B cell apoptotic process, B cell homeostasis, epithelial cell migration, histone H3-T11 phosphorylation, hyperosmotic response, intracellular signal transduction, negative regulation of B cell proliferation, negative regulation of protein kinase activity, peptidyl-...
activation of JUN kinase activity, B cell apoptotic process, B cell homeostasis, epithelial cell migration, histone H3-T11 phosphorylation, hyperosmotic response, intracellular signal transduction, negative regulation of B cell proliferation, negative regulation of protein kinase activity, peptidyl-serine phosphorylation, protein phosphorylation, regulation of cell motility, regulation of germinal center formation, regulation of immunoglobulin production, regulation of transcription by RNA polymerase II, renal system process, signal transduction, spleen development
View more >>
GO - Molecular function (MF):
androgen receptor binding, ATP binding, calcium-dependent protein kinase C activity, chromatin binding, GTP-Rho binding, histone binding, histone deacetylase binding, histone kinase activity (H3-T11 specific), nuclear receptor transcription coactivator activity, protein kinase activity, protein kina...
androgen receptor binding, ATP binding, calcium-dependent protein kinase C activity, chromatin binding, GTP-Rho binding, histone binding, histone deacetylase binding, histone kinase activity (H3-T11 specific), nuclear receptor transcription coactivator activity, protein kinase activity, protein kinase C binding, protein serine/threonine kinase activity, Rac GTPase binding
View more >>
GO - Cellular component (CC):
cytosol, endosome, nucleoplasm, nucleus, cleavage furrow, cytoplasm, midbody, protein-containing complex...
cytosol, endosome, nucleoplasm, nucleus, cleavage furrow, cytoplasm, midbody, protein-containing complex
View more >>
protein kinase N1
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for PKN1 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc