PKN2
Entrez ID: 5586
Full name: protein kinase N2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: PKN
Chromosomal location: 1p22.2
Substructure location: Gatekeeper: 737 A-loop: 799...822 G-loop: 663...672 αC-helix: 690...695
Please click HERE
for better display.
PKN2
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcriptio...
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747).
View more >>
GO - Biological processes (BP):
apical junction assembly, apoptotic process, cell adhesion, cell cycle, cell division, cell projection organization, epithelial cell migration, intracellular signal transduction, peptidyl-serine phosphorylation, positive regulation of cytokinesis, positive regulation of mitotic cell cycle, positive ...
apical junction assembly, apoptotic process, cell adhesion, cell cycle, cell division, cell projection organization, epithelial cell migration, intracellular signal transduction, peptidyl-serine phosphorylation, positive regulation of cytokinesis, positive regulation of mitotic cell cycle, positive regulation of viral genome replication, protein phosphorylation, regulation of cell motility, signal transduction, viral process
View more >>
GO - Molecular function (MF):
ATP binding, cadherin binding, calcium-dependent protein kinase C activity, GTP-Rho binding, histone deacetylase binding, kinase activity, protein kinase activity, protein serine/threonine kinase activity, RNA binding, RNA polymerase binding...
ATP binding, cadherin binding, calcium-dependent protein kinase C activity, GTP-Rho binding, histone deacetylase binding, kinase activity, protein kinase activity, protein serine/threonine kinase activity, RNA binding, RNA polymerase binding
View more >>
GO - Cellular component (CC):
centrosome, intermediate filament cytoskeleton, cytosol, nuclear body, nucleoplasm, nucleus, cleavage furrow, plasma membrane, apical junction complex, cytoplasm, lamellipodium, midbody, perinuclear region of cytoplasm, protein-containing complex...
centrosome, intermediate filament cytoskeleton, cytosol, nuclear body, nucleoplasm, nucleus, cleavage furrow, plasma membrane, apical junction complex, cytoplasm, lamellipodium, midbody, perinuclear region of cytoplasm, protein-containing complex
View more >>
protein kinase N2
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for PKN2 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc