CAMK4
Entrez ID: 814
Full name: calcium/calmodulin dependent protein kinase IV
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMK1
Chromosomal location: 5q22.1
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 91...95
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CAMK4
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, ...
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
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GO - Biological processes (BP):
adaptive immune response, inflammatory response, intracellular signal transduction, long-term memory, myeloid dendritic cell differentiation, peptidyl-serine phosphorylation, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein phosphorylation, regulation of oste...
adaptive immune response, inflammatory response, intracellular signal transduction, long-term memory, myeloid dendritic cell differentiation, peptidyl-serine phosphorylation, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein phosphorylation, regulation of osteoclast differentiation, regulation of T cell differentiation in thymus, signal transduction
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GO - Molecular function (MF):
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, calmodulin-dependent protein kinase activity...
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, calmodulin-dependent protein kinase activity
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GO - Cellular component (CC):
extracellular exosome, fibrillar center, nucleoplasm, nucleus, cytoplasm, glutamatergic synapse, postsynapse...
extracellular exosome, fibrillar center, nucleoplasm, nucleus, cytoplasm, glutamatergic synapse, postsynapse
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calcium/calmodulin dependent protein kinase IV
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A-loop
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Kaplan plot for CAMK4 in
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*NOTE: the Kaplan plots were collected from OncoLnc