MAP3K11
Entrez ID: 4296
Full name: mitogen-activated protein kinase kinase kinase 11
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: MLK: MLK
Chromosomal location: 11q13.1
Substructure location: Gatekeeper: 193 A-loop: 266...287 G-loop: [N/A] αC-helix: [N/A]
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MAP3K11
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and a...
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
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GO - Biological processes (BP):
activation of JUN kinase activity, activation of MAPK activity, cell cycle G1/S phase transition, cell death, JNK cascade, microtubule-based process, positive regulation of apoptotic process, positive regulation of JNK cascade, positive regulation of JUN kinase activity, positive regulation of neuro...
activation of JUN kinase activity, activation of MAPK activity, cell cycle G1/S phase transition, cell death, JNK cascade, microtubule-based process, positive regulation of apoptotic process, positive regulation of JNK cascade, positive regulation of JUN kinase activity, positive regulation of neuron apoptotic process, protein autophosphorylation, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, identical protein binding, JUN kinase kinase kinase activity, mitogen-activated protein kinase kinase binding, mitogen-activated protein kinase kinase kinase binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, Rac GTPase binding...
ATP binding, identical protein binding, JUN kinase kinase kinase activity, mitogen-activated protein kinase kinase binding, mitogen-activated protein kinase kinase kinase binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, Rac GTPase binding
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GO - Cellular component (CC):
centrosome, microtubule, cytoplasm, membrane...
centrosome, microtubule, cytoplasm, membrane
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mitogen-activated protein kinase kinase kinase 11
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Kaplan plot for MAP3K11 in
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*NOTE: the Kaplan plots were collected from OncoLnc