NTRK2
Entrez ID: 4915
Full name: neurotrophic receptor tyrosine kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Trk
Chromosomal location: 9q21.33
Substructure location: Gatekeeper: 617 A-loop: 693...718 G-loop: 543...554 αC-helix: 579...592
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NTRK2
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotroph...
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
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GO - Biological processes (BP):
activation of phospholipase C activity, brain-derived neurotrophic factor receptor signaling pathway, cellular response to amino acid stimulus, cellular response to brain-derived neurotrophic factor stimulus, cellular response to nerve growth factor stimulus, central nervous system neuron developmen...
activation of phospholipase C activity, brain-derived neurotrophic factor receptor signaling pathway, cellular response to amino acid stimulus, cellular response to brain-derived neurotrophic factor stimulus, cellular response to nerve growth factor stimulus, central nervous system neuron development, cerebral cortex development, circadian rhythm, feeding behavior, glutamate secretion, learning, long-term synaptic potentiation, mechanoreceptor differentiation, multicellular organism development, myelination in peripheral nervous system, negative regulation of anoikis, negative regulation of neuron apoptotic process, nervous system development, neuronal action potential propagation, neuron differentiation, neuron migration, neurotrophin TRK receptor signaling pathway, oligodendrocyte differentiation, peripheral nervous system neuron development, positive regulation of axonogenesis, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of neuron projection development, positive regulation of non-membrane spanning protein tyrosine kinase activity, positive regulation of peptidyl-serine phosphorylation, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein phosphorylation, positive regulation of synapse assembly, protein autophosphorylation, regulation of GTPase activity, regulation of MAPK cascade, regulation of protein kinase B signaling, retinal rod cell development, transmembrane receptor protein tyrosine kinase signaling pathway, trans-synaptic signaling by BDNF, modulating synaptic transmission, trans-synaptic signaling by neuropeptide, modulating synaptic transmission, vasculogenesis
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GO - Molecular function (MF):
ATP binding, brain-derived neurotrophic factor-activated receptor activity, brain-derived neurotrophic factor binding, neurotrophin binding, neurotrophin receptor activity, protein homodimerization activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, brain-derived neurotrophic factor-activated receptor activity, brain-derived neurotrophic factor binding, neurotrophin binding, neurotrophin receptor activity, protein homodimerization activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, early endosome, early endosome membrane, Golgi membrane, integral component of plasma membrane, plasma membrane, axon, axon terminus, cell junction, dendrite, dendritic spine, perinuclear region of cytoplasm, postsynaptic density, receptor complex, terminal bouton...
cytosol, early endosome, early endosome membrane, Golgi membrane, integral component of plasma membrane, plasma membrane, axon, axon terminus, cell junction, dendrite, dendritic spine, perinuclear region of cytoplasm, postsynaptic density, receptor complex, terminal bouton
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neurotrophic receptor tyrosine kinase 2
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*NOTE: the Kaplan plots were collected from OncoLnc