PDK4
Entrez ID: 5166
Full name: pyruvate dehydrogenase kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: PDPK1
Chromosomal location: 7q21.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PDK4
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-...
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
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GO - Biological processes (BP):
cellular response to fatty acid, cellular response to starvation, glucose homeostasis, glucose metabolic process, insulin receptor signaling pathway, negative regulation of anoikis, negative regulation of pyruvate dehydrogenase activity, reactive oxygen species metabolic process, regulation of acety...
cellular response to fatty acid, cellular response to starvation, glucose homeostasis, glucose metabolic process, insulin receptor signaling pathway, negative regulation of anoikis, negative regulation of pyruvate dehydrogenase activity, reactive oxygen species metabolic process, regulation of acetyl-CoA biosynthetic process from pyruvate, regulation of bone resorption, regulation of cellular ketone metabolic process, regulation of fatty acid biosynthetic process, regulation of fatty acid oxidation, regulation of glucose metabolic process, regulation of pH, response to starvation
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity
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GO - Cellular component (CC):
mitochondrial matrix, mitochondrion...
mitochondrial matrix, mitochondrion
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pyruvate dehydrogenase kinase 4
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Kaplan plot for PDK4 in
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*NOTE: the Kaplan plots were collected from OncoLnc