MAPK6
Entrez ID: 5597
Full name: mitogen-activated protein kinase 6
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: MAPK: ERK3
Chromosomal location: 15q21.2
Substructure location: Gatekeeper: 113 A-loop: 170...196 G-loop: 23...36 αC-helix: 56...70
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MAPK6
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at...
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
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GO - Biological processes (BP):
cell cycle, cellular response to organic substance, intracellular signal transduction, positive regulation of dendritic spine development, protein phosphorylation, regulation of gene expression, signal transduction...
cell cycle, cellular response to organic substance, intracellular signal transduction, positive regulation of dendritic spine development, protein phosphorylation, regulation of gene expression, signal transduction
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GO - Molecular function (MF):
ATP binding, MAP kinase activity, protein heterodimerization activity, protein kinase binding, protein serine/threonine kinase activity...
ATP binding, MAP kinase activity, protein heterodimerization activity, protein kinase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
septin cytoskeleton, cytosol, nucleoplasm, nucleus, cytoplasm, protein-containing complex...
septin cytoskeleton, cytosol, nucleoplasm, nucleus, cytoplasm, protein-containing complex
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mitogen-activated protein kinase 6
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*NOTE: the Kaplan plots were collected from OncoLnc