AAK1
Entrez ID: 22848
Full name: AP2 associated kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NAK: BIKE
Chromosomal location: 2p13.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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AAK1
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity ...
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
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GO - Biological processes (BP):
endocytosis, membrane organization, positive regulation of Notch signaling pathway, protein autophosphorylation, protein phosphorylation, protein stabilization, regulation of clathrin-dependent endocytosis, regulation of protein localization...
endocytosis, membrane organization, positive regulation of Notch signaling pathway, protein autophosphorylation, protein phosphorylation, protein stabilization, regulation of clathrin-dependent endocytosis, regulation of protein localization
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GO - Molecular function (MF):
AP-2 adaptor complex binding, ATP binding, Notch binding, protein serine/threonine kinase activity...
AP-2 adaptor complex binding, ATP binding, Notch binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus, extrinsic component of plasma membrane, cell junction, cell leading edge, clathrin-coated pit, clathrin-coated vesicle, terminal bouton...
cytosol, nucleus, extrinsic component of plasma membrane, cell junction, cell leading edge, clathrin-coated pit, clathrin-coated vesicle, terminal bouton
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AP2 associated kinase 1
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Kaplan plot for AAK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc