PKDCC
Entrez ID: 91461
Full name: protein kinase domain containing, cytoplasmic
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: SgK493
Chromosomal location: 2p21
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PKDCC
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a ro...
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).
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GO - Biological processes (BP):
bone mineralization, cell differentiation, embryonic digestive tract development, limb morphogenesis, lung alveolus development, multicellular organism growth, negative regulation of Golgi to plasma membrane protein transport, peptidyl-tyrosine phosphorylation, positive regulation of bone mineraliza...
bone mineralization, cell differentiation, embryonic digestive tract development, limb morphogenesis, lung alveolus development, multicellular organism growth, negative regulation of Golgi to plasma membrane protein transport, peptidyl-tyrosine phosphorylation, positive regulation of bone mineralization, positive regulation of chondrocyte differentiation, protein transport, roof of mouth development, skeletal system development
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GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity...
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity
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GO - Cellular component (CC):
extracellular region, Golgi apparatus...
extracellular region, Golgi apparatus
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protein kinase domain containing, cytoplasmic
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*NOTE: the Kaplan plots were collected from OncoLnc