PAN3
Entrez ID: 255967
Full name: poly(A) specific ribonuclease subunit PAN3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: PAN3
Chromosomal location: 13q12.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PAN3
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is...
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
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GO - Biological processes (BP):
deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA processing, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of cytoplasmic mRNA processing body assembly, protein targeting, RNA phosphodiester bond hydrolysis, exonucleolytic...
deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA processing, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of cytoplasmic mRNA processing body assembly, protein targeting, RNA phosphodiester bond hydrolysis, exonucleolytic
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein kinase activity, RNA binding...
ATP binding, metal ion binding, protein kinase activity, RNA binding
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GO - Cellular component (CC):
cytosol, P-body, PAN complex...
cytosol, P-body, PAN complex
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poly(A) specific ribonuclease subunit PAN3
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*NOTE: the Kaplan plots were collected from OncoLnc