BRDT
Entrez ID: 676
Full name: bromodomain testis associated
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: BRD
Chromosomal location: 1p22.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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BRDT
Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cell...
Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed:22901802). In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.
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GO - Biological processes (BP):
cell differentiation, chromatin remodeling, histone displacement, male meiosis I, male meiotic nuclear division, mRNA processing, positive regulation of transcription involved in meiotic cell cycle, regulation of RNA splicing, regulation of transcription, DNA-templated, RNA splicing, spermatogenesis...
cell differentiation, chromatin remodeling, histone displacement, male meiosis I, male meiotic nuclear division, mRNA processing, positive regulation of transcription involved in meiotic cell cycle, regulation of RNA splicing, regulation of transcription, DNA-templated, RNA splicing, spermatogenesis
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GO - Molecular function (MF):
histone binding, lysine-acetylated histone binding, transcription coactivator activity...
histone binding, lysine-acetylated histone binding, transcription coactivator activity
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GO - Cellular component (CC):
nucleus...
nucleus
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bromodomain testis associated
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Kaplan plot for BRDT in
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*NOTE: the Kaplan plots were collected from OncoLnc