TTBK1
Entrez ID: 84630
Full name: tau tubulin kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CK1: TTBK
Chromosomal location: 6p21.1
Substructure location: Gatekeeper: 107 A-loop: 175...181, 201...204 G-loop: [N/A] αC-helix: 74...83
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TTBK1
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU....
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
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GO - Biological processes (BP):
learning or memory, negative regulation of gene expression, negative regulation of protein binding, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of astrocyte activation, positive regulation of cyclin-dependent protein kin...
learning or memory, negative regulation of gene expression, negative regulation of protein binding, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of astrocyte activation, positive regulation of cyclin-dependent protein kinase activity, positive regulation of cysteine-type endopeptidase activity, positive regulation of gene expression, positive regulation of microglial cell activation, positive regulation of protein polymerization, protein phosphorylation, substantia nigra development
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity, protein tyrosine kinase activity, tau protein binding, tau-protein kinase activity...
ATP binding, protein serine/threonine kinase activity, protein tyrosine kinase activity, tau protein binding, tau-protein kinase activity
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GO - Cellular component (CC):
microtubule associated complex, cytosol, nucleoplasm, nucleus, cytoplasm, neuronal cell body, perinuclear region of cytoplasm...
microtubule associated complex, cytosol, nucleoplasm, nucleus, cytoplasm, neuronal cell body, perinuclear region of cytoplasm
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tau tubulin kinase 1
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for TTBK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc