OBSCN
Entrez ID: 84033
Full name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: Trio
Chromosomal location: 1q42.13
Substructure location: Gatekeeper: 7745 A-loop: 6606...6628, 7808...7832 G-loop: [N/A] αC-helix: [N/A]
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OBSCN
Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/pot...
Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4-phosphate (PtdIns4P), phosphatidylinositol 5-phosphate (PtdIns5P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662).
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GO - Biological processes (BP):
G protein-coupled receptor signaling pathway, multicellular organism development, positive regulation of apoptotic process, protein localization to M-band, regulation of small GTPase mediated signal transduction, sarcomere organization...
G protein-coupled receptor signaling pathway, multicellular organism development, positive regulation of apoptotic process, protein localization to M-band, regulation of small GTPase mediated signal transduction, sarcomere organization
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GO - Molecular function (MF):
ankyrin binding, ATP binding, calmodulin binding, guanyl-nucleotide exchange factor activity, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding, p...
ankyrin binding, ATP binding, calmodulin binding, guanyl-nucleotide exchange factor activity, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding, protein serine/threonine kinase activity, structural constituent of muscle, titin binding
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GO - Cellular component (CC):
cytosol, nuclear body, plasma membrane, sarcolemma, M band, myofibril, Z disc...
cytosol, nuclear body, plasma membrane, sarcolemma, M band, myofibril, Z disc
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obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
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*NOTE: the Kaplan plots were collected from OncoLnc