CDC42BPA
Entrez ID: 8476
Full name: CDC42 binding protein kinase alpha
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: DMPK: GEK
Chromosomal location: 1q42.13
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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CDC42BPA
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and M...
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624).
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GO - Biological processes (BP):
actin cytoskeleton reorganization, actomyosin structure organization, cell migration, intracellular signal transduction, peptidyl-threonine phosphorylation, protein phosphorylation...
actin cytoskeleton reorganization, actomyosin structure organization, cell migration, intracellular signal transduction, peptidyl-threonine phosphorylation, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, identical protein binding, magnesium ion binding, protein serine/threonine kinase activity...
ATP binding, identical protein binding, magnesium ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
actomyosin, cytoskeleton, extracellular exosome, cell leading edge, cell-cell junction, cytoplasm, lamellipodium...
actomyosin, cytoskeleton, extracellular exosome, cell leading edge, cell-cell junction, cytoplasm, lamellipodium
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CDC42 binding protein kinase alpha
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Kaplan plot for CDC42BPA in
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*NOTE: the Kaplan plots were collected from OncoLnc