TTBK2
Entrez ID: 146057
Full name: tau tubulin kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CK1: TTBK
Chromosomal location: 15q15.2
Substructure location: Gatekeeper: 94 A-loop: 162...168, 188...191 G-loop: [N/A] αC-helix: [N/A]
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TTBK2
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axone...
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
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GO - Biological processes (BP):
cerebellar granular layer development, cerebellar granule cell precursor tangential migration, cerebellum development, ciliary basal body-plasma membrane docking, cilium assembly, microtubule cytoskeleton organization, negative regulation of microtubule binding, negative regulation of microtubule de...
cerebellar granular layer development, cerebellar granule cell precursor tangential migration, cerebellum development, ciliary basal body-plasma membrane docking, cilium assembly, microtubule cytoskeleton organization, negative regulation of microtubule binding, negative regulation of microtubule depolymerization, negative regulation of protein localization to microtubule, peptidyl-serine phosphorylation, regulation of cell migration, smoothened signaling pathway
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GO - Molecular function (MF):
ATP binding, kinesin binding, microtubule plus-end binding, protein kinase activity, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity...
ATP binding, kinesin binding, microtubule plus-end binding, protein kinase activity, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity
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GO - Cellular component (CC):
centriole, ciliary basal body, cytosol, extracellular space, nucleus, ciliary transition zone, cytoplasm...
centriole, ciliary basal body, cytosol, extracellular space, nucleus, ciliary transition zone, cytoplasm
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tau tubulin kinase 2
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Kaplan plot for TTBK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc