MAST2
Entrez ID: 23139
Full name: microtubule associated serine/threonine kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: MAST: MAST
Chromosomal location: 1p34.1
Substructure location: Gatekeeper: 589 A-loop: 652...662, 682...690 G-loop: [N/A] αC-helix: [N/A]
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MAST2
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in ...
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).
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GO - Biological processes (BP):
cytoskeleton organization, intracellular signal transduction, peptidyl-serine phosphorylation, protein phosphorylation, regulation of interleukin-12 biosynthetic process, spermatid differentiation...
cytoskeleton organization, intracellular signal transduction, peptidyl-serine phosphorylation, protein phosphorylation, regulation of interleukin-12 biosynthetic process, spermatid differentiation
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, microtubule binding, phosphatase binding, protein serine/threonine kinase activity...
ATP binding, magnesium ion binding, microtubule binding, phosphatase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
microtubule cytoskeleton, plasma membrane, cytoplasm...
microtubule cytoskeleton, plasma membrane, cytoplasm
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microtubule associated serine/threonine kinase 2
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*NOTE: the Kaplan plots were collected from OncoLnc