TSSK4
Entrez ID: 283629
Full name: testis specific serine kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: TSSK
Chromosomal location: 14q12
Substructure location: Gatekeeper: 102 A-loop: 165...176, 193...203 G-loop: [N/A] αC-helix: [N/A]
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TSSK4
Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphory...
Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity).
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GO - Biological processes (BP):
fertilization, flagellated sperm motility, intracellular signal transduction, multicellular organism development, peptidyl-serine phosphorylation, peptidyl-threonine autophosphorylation, positive regulation of CREB transcription factor activity, protein phosphorylation, spermatid development...
fertilization, flagellated sperm motility, intracellular signal transduction, multicellular organism development, peptidyl-serine phosphorylation, peptidyl-threonine autophosphorylation, positive regulation of CREB transcription factor activity, protein phosphorylation, spermatid development
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein-containing complex binding, protein homodimerization activity, protein serine/threonine kinase activity...
ATP binding, magnesium ion binding, protein-containing complex binding, protein homodimerization activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleus, acrosomal vesicle, cytoplasm, sperm flagellum...
nucleus, acrosomal vesicle, cytoplasm, sperm flagellum
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testis specific serine kinase 4
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*NOTE: the Kaplan plots were collected from OncoLnc