KSR2
Entrez ID: 283455
Full name: kinase suppressor of ras 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: RAF: KSR
Chromosomal location: 12q24.22-q24.23
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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KSR2
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and p...
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
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GO - Biological processes (BP):
calcium-mediated signaling, positive regulation of cold-induced thermogenesis, Ras protein signal transduction...
calcium-mediated signaling, positive regulation of cold-induced thermogenesis, Ras protein signal transduction
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, plasma membrane...
cytosol, plasma membrane
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kinase suppressor of ras 2
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G-loop
αC-helix
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Kaplan plot for KSR2 in
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*NOTE: the Kaplan plots were collected from OncoLnc