DSTYK
Entrez ID: 25778
Full name: dual serine/threonine and tyrosine protein kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: Dusty
Chromosomal location: 1q32.1
Substructure location: Gatekeeper: 730 A-loop: 794...814 G-loop: [N/A] αC-helix: [N/A]
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DSTYK
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant ...
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540).
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GO - Biological processes (BP):
cellular response to fibroblast growth factor stimulus, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of kinase activity...
cellular response to fibroblast growth factor stimulus, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of kinase activity
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GO - Molecular function (MF):
ATP binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
apical plasma membrane, basolateral plasma membrane, cell junction, cytoplasm...
apical plasma membrane, basolateral plasma membrane, cell junction, cytoplasm
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dual serine/threonine and tyrosine protein kinase
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*NOTE: the Kaplan plots were collected from OncoLnc