ERN2
Entrez ID: 10595
Full name: endoplasmic reticulum to nucleus signaling 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: IRE
Chromosomal location: 16p12.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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ERN2
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins....
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
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GO - Biological processes (BP):
activation of JUN kinase activity, apoptotic chromosome condensation, cell cycle arrest, endoplasmic reticulum unfolded protein response, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, IRE1-mediated unfolded protein response, mRNA processing, negative regulation o...
activation of JUN kinase activity, apoptotic chromosome condensation, cell cycle arrest, endoplasmic reticulum unfolded protein response, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, IRE1-mediated unfolded protein response, mRNA processing, negative regulation of transcription, DNA-templated, protein phosphorylation, response to endoplasmic reticulum stress, rRNA catabolic process
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GO - Molecular function (MF):
ATP binding, endonuclease activity, endoribonuclease activity, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity, unfolded protein binding...
ATP binding, endonuclease activity, endoribonuclease activity, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity, unfolded protein binding
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GO - Cellular component (CC):
endoplasmic reticulum membrane, IRE1-TRAF2-ASK1 complex, integral component of membrane...
endoplasmic reticulum membrane, IRE1-TRAF2-ASK1 complex, integral component of membrane
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endoplasmic reticulum to nucleus signaling 2
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*NOTE: the Kaplan plots were collected from OncoLnc