MARK2
Entrez ID: 2011
Full name: microtubule affinity regulating kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: MARK
Chromosomal location: 11q13.1
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 58...68 αC-helix: 91...106
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MARK2
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity ...
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
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GO - Biological processes (BP):
activation of protein kinase activity, autophagy of mitochondrion, axon development, establishment of cell polarity, establishment or maintenance of cell polarity regulating cell shape, establishment or maintenance of epithelial cell apical/basal polarity, intracellular signal transduction, microtub...
activation of protein kinase activity, autophagy of mitochondrion, axon development, establishment of cell polarity, establishment or maintenance of cell polarity regulating cell shape, establishment or maintenance of epithelial cell apical/basal polarity, intracellular signal transduction, microtubule cytoskeleton organization, mitochondrion localization, neuron migration, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of neuron projection development, protein autophosphorylation, protein phosphorylation, regulation of axonogenesis, regulation of cytoskeleton organization, regulation of microtubule binding, regulation of microtubule cytoskeleton organization, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, cadherin binding, lipid binding, magnesium ion binding, protein kinase activator activity, protein serine/threonine kinase activity, RNA binding, tau protein binding, tau-protein kinase activity...
ATP binding, cadherin binding, lipid binding, magnesium ion binding, protein kinase activator activity, protein serine/threonine kinase activity, RNA binding, tau protein binding, tau-protein kinase activity
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GO - Cellular component (CC):
actin filament, microtubule bundle, mitochondrion, nucleoplasm, lateral plasma membrane, plasma membrane, cytoplasm, dendrite, membrane...
actin filament, microtubule bundle, mitochondrion, nucleoplasm, lateral plasma membrane, plasma membrane, cytoplasm, dendrite, membrane
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microtubule affinity regulating kinase 2
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*NOTE: the Kaplan plots were collected from OncoLnc