TAOK1
Entrez ID: 57551
Full name: TAO kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: TAO
Chromosomal location: 17q11.2
Substructure location: Gatekeeper: 105 A-loop: 168...187 G-loop: [N/A] αC-helix: [N/A]
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TAOK1
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating pho...
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
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GO - Biological processes (BP):
activation of JUN kinase activity, activation of MAPK activity, activation of MAPKK activity, activation of protein kinase activity, cellular response to DNA damage stimulus, DNA repair, execution phase of apoptosis, microtubule cytoskeleton organization, mitotic G2 DNA damage checkpoint, negative r...
activation of JUN kinase activity, activation of MAPK activity, activation of MAPKK activity, activation of protein kinase activity, cellular response to DNA damage stimulus, DNA repair, execution phase of apoptosis, microtubule cytoskeleton organization, mitotic G2 DNA damage checkpoint, negative regulation of microtubule depolymerization, neuron cellular homeostasis, phosphorylation, positive regulation of JNK cascade, positive regulation of protein acetylation, positive regulation of stress-activated MAPK cascade, protein autophosphorylation, protein phosphorylation, regulation of actin cytoskeleton organization, regulation of cytoskeleton organization, regulation of microtubule cytoskeleton organization, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
alpha-tubulin binding, ATP binding, beta-tubulin binding, kinase activity, MAP kinase kinase kinase activity, protein kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity, transferase activity...
alpha-tubulin binding, ATP binding, beta-tubulin binding, kinase activity, MAP kinase kinase kinase activity, protein kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity, transferase activity
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GO - Cellular component (CC):
microtubule cytoskeleton, cytosol, extracellular exosome, cell, cytoplasm, perinuclear region of cytoplasm...
microtubule cytoskeleton, cytosol, extracellular exosome, cell, cytoplasm, perinuclear region of cytoplasm
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TAO kinase 1
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Kaplan plot for TAOK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc