STRADA
Entrez ID: 92335
Full name: STE20 related adaptor alpha
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: STLK
Chromosomal location: 17q23.3
Substructure location: Gatekeeper: 147 A-loop: [N/A] G-loop: [N/A] αC-helix: 104...106
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STRADA
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation....
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
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GO - Biological processes (BP):
activation of protein kinase activity, cell cycle arrest, protein export from nucleus, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade...
activation of protein kinase activity, cell cycle arrest, protein export from nucleus, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, kinase binding, protein kinase activator activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity...
ATP binding, kinase binding, protein kinase activator activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, cytoplasm...
cytosol, nucleoplasm, nucleus, cytoplasm
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STE20 related adaptor alpha
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A-loop
G-loop
αC-helix
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αC-helix
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*NOTE: the Kaplan plots were collected from OncoLnc