NEK8
Entrez ID: 284086
Full name: NIMA related kinase 8
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NEK: NEK8
Chromosomal location: 17q11.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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NEK8
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathwa...
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
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GO - Biological processes (BP):
animal organ morphogenesis, chromosome segregation, determination of left/right symmetry, heart development, regulation of hippo signaling...
animal organ morphogenesis, chromosome segregation, determination of left/right symmetry, heart development, regulation of hippo signaling
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centrosome, nucleus, ciliary base, ciliary inversin compartment, cilium, cytoplasm...
centrosome, nucleus, ciliary base, ciliary inversin compartment, cilium, cytoplasm
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NIMA related kinase 8
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for NEK8 in
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*NOTE: the Kaplan plots were collected from OncoLnc