TLK2
Entrez ID: 11011
Full name: tousled like kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: TLK
Chromosomal location: 17q23.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
Please click HERE
for better display.
TLK2
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, th...
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
View more >>
GO - Biological processes (BP):
cell cycle, cellular response to DNA damage stimulus, cellular response to gamma radiation, chromatin organization, chromosome segregation, intracellular signal transduction, negative regulation of autophagy, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, peptidyl-...
cell cycle, cellular response to DNA damage stimulus, cellular response to gamma radiation, chromatin organization, chromosome segregation, intracellular signal transduction, negative regulation of autophagy, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, peptidyl-serine phosphorylation, protein phosphorylation, regulation of chromatin assembly or disassembly
View more >>
GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
intermediate filament, nucleus, perinuclear region of cytoplasm...
intermediate filament, nucleus, perinuclear region of cytoplasm
View more >>
tousled like kinase 2
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for TLK2 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc