VRK2
Entrez ID: 7444
Full name: VRK serine/threonine kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CK1: VRK
Chromosomal location: 2p16.1
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 32...45 αC-helix: 53...55
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VRK2
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. ...
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
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GO - Biological processes (BP):
cellular response to oxidative stress, peptidyl-serine phosphorylation, protein autophosphorylation, protein phosphorylation, regulation of interleukin-1-mediated signaling pathway, regulation of MAPK cascade, viral process, Wnt signaling pathway...
cellular response to oxidative stress, peptidyl-serine phosphorylation, protein autophosphorylation, protein phosphorylation, regulation of interleukin-1-mediated signaling pathway, regulation of MAPK cascade, viral process, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, protein domain specific binding, protein kinase binding, protein serine/threonine kinase activity...
ATP binding, protein domain specific binding, protein kinase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
endoplasmic reticulum, endoplasmic reticulum membrane, mitochondrial membrane, nuclear envelope, nucleus, cytoplasm, integral component of membrane, protein-containing complex...
endoplasmic reticulum, endoplasmic reticulum membrane, mitochondrial membrane, nuclear envelope, nucleus, cytoplasm, integral component of membrane, protein-containing complex
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VRK serine/threonine kinase 2
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*NOTE: the Kaplan plots were collected from OncoLnc