PRAG1
Entrez ID: 157285
Full name: PEAK1 related, kinase-activating pseudokinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NKF3
Chromosomal location: 8p23.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PRAG1
Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization o...
Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity).
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GO - Biological processes (BP):
cell migration, negative regulation of neuron projection development, positive regulation of Rho protein signal transduction, protein phosphorylation, regulation of cell motility, regulation of cell shape, regulation of Notch signaling pathway...
cell migration, negative regulation of neuron projection development, positive regulation of Rho protein signal transduction, protein phosphorylation, regulation of cell motility, regulation of cell shape, regulation of Notch signaling pathway
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GO - Molecular function (MF):
identical protein binding, protein kinase activity...
identical protein binding, protein kinase activity
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GO - Cellular component (CC):
nucleus, cytoplasm, focal adhesion...
nucleus, cytoplasm, focal adhesion
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PEAK1 related, kinase-activating pseudokinase 1
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Kaplan plot for PRAG1 in
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*NOTE: the Kaplan plots were collected from OncoLnc