HIPK1
Entrez ID: 204851
Full name: homeodomain interacting protein kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: DYRK: HIPK
Chromosomal location: 1p13.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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HIPK1
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to th...
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171).
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GO - Biological processes (BP):
adherens junction assembly, anterior/posterior pattern specification, definitive hemopoiesis, embryonic camera-type eye morphogenesis, embryonic retina morphogenesis in camera-type eye, endothelial cell apoptotic process, extrinsic apoptotic signaling pathway, eye development, intrinsic apoptotic si...
adherens junction assembly, anterior/posterior pattern specification, definitive hemopoiesis, embryonic camera-type eye morphogenesis, embryonic retina morphogenesis in camera-type eye, endothelial cell apoptotic process, extrinsic apoptotic signaling pathway, eye development, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, iris morphogenesis, lens induction in camera-type eye, neuron differentiation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of angiogenesis, positive regulation of cell population proliferation, protein phosphorylation, regulation of signal transduction by p53 class mediator, regulation of tumor necrosis factor-mediated signaling pathway, retina layer formation, smoothened signaling pathway
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
centrosome, cytosol, nuclear speck, nucleoplasm, nucleus, PML body, cytoplasm...
centrosome, cytosol, nuclear speck, nucleoplasm, nucleus, PML body, cytoplasm
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homeodomain interacting protein kinase 1
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A-loop
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Kaplan plot for HIPK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc