KSR1
Entrez ID: 8844
Full name: kinase suppressor of ras 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: RAF: KSR
Chromosomal location: 17q11.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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KSR1
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP...
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity).
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GO - Biological processes (BP):
activation of MAPKKK activity, cAMP-mediated signaling, MAPK cascade, positive regulation of MAPK cascade, Ras protein signal transduction, regulation of cell population proliferation, regulation of MAP kinase activity...
activation of MAPKKK activity, cAMP-mediated signaling, MAPK cascade, positive regulation of MAPK cascade, Ras protein signal transduction, regulation of cell population proliferation, regulation of MAP kinase activity
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GO - Molecular function (MF):
14-3-3 protein binding, ATP binding, chaperone binding, Hsp90 protein binding, MAP-kinase scaffold activity, metal ion binding, mitogen-activated protein kinase kinase binding, protein C-terminus binding, protein serine/threonine kinase activity...
14-3-3 protein binding, ATP binding, chaperone binding, Hsp90 protein binding, MAP-kinase scaffold activity, metal ion binding, mitogen-activated protein kinase kinase binding, protein C-terminus binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, ruffle membrane, membrane, protein-containing complex...
cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, ruffle membrane, membrane, protein-containing complex
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kinase suppressor of ras 1
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Kaplan plot for KSR1 in
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*NOTE: the Kaplan plots were collected from OncoLnc