MAPKAPK5
Entrez ID: 8550
Full name: MAPK activated protein kinase 5
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: MAPKAPK: MK5
Chromosomal location: 12q24.12-q24.13
Substructure location: Gatekeeper: 102 A-loop: 168...178, 180...188 G-loop: [N/A] αC-helix: [N/A]
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MAPKAPK5
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in po...
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
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GO - Biological processes (BP):
intracellular signal transduction, negative regulation of TOR signaling, peptidyl-serine phosphorylation, positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, protein autophosphorylation, Ras protein signal t...
intracellular signal transduction, negative regulation of TOR signaling, peptidyl-serine phosphorylation, positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, protein autophosphorylation, Ras protein signal transduction, regulation of signal transduction by p53 class mediator, regulation of translation, signal transduction, stress-induced premature senescence
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GO - Molecular function (MF):
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, MAP kinase kinase activity, mitogen-activated protein kinase binding, p53 binding, protein serine/threonine kinase activity...
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, MAP kinase kinase activity, mitogen-activated protein kinase binding, p53 binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, cytoplasm...
cytosol, nucleoplasm, nucleus, cytoplasm
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MAPK activated protein kinase 5
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*NOTE: the Kaplan plots were collected from OncoLnc