TEX14
Entrez ID: 56155
Full name: testis expressed 14, intercellular bridge forming factor
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NKF5
Chromosomal location: 17q22
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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TEX14
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by pr...
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).
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GO - Biological processes (BP):
attachment of spindle microtubules to kinetochore, cell division, cellular response to leukemia inhibitory factor, intercellular bridge organization, male meiotic nuclear division, mitotic sister chromatid separation, mitotic spindle assembly checkpoint, negative regulation of cytokinesis, negative ...
attachment of spindle microtubules to kinetochore, cell division, cellular response to leukemia inhibitory factor, intercellular bridge organization, male meiotic nuclear division, mitotic sister chromatid separation, mitotic spindle assembly checkpoint, negative regulation of cytokinesis, negative regulation of protein binding
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein kinase binding...
ATP binding, protein kinase activity, protein kinase binding
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GO - Cellular component (CC):
extracellular exosome, intercellular bridge, cell, condensed chromosome kinetochore, cytoplasm, kinetochore, midbody...
extracellular exosome, intercellular bridge, cell, condensed chromosome kinetochore, cytoplasm, kinetochore, midbody
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testis expressed 14, intercellular bridge forming factor
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Kaplan plot for TEX14 in
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*NOTE: the Kaplan plots were collected from OncoLnc