FAM20C
Entrez ID: 56975
Full name: FAM20C golgi associated secretory pathway kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: PKL: FJ
Chromosomal location: 7p22.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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FAM20C
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generati...
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).
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GO - Biological processes (BP):
ATP metabolic process, biomineral tissue development, cellular protein metabolic process, dentinogenesis, enamel mineralization, odontoblast differentiation, osteoclast maturation, phosphorylation, positive regulation of bone mineralization, positive regulation of osteoblast differentiation, post-tr...
ATP metabolic process, biomineral tissue development, cellular protein metabolic process, dentinogenesis, enamel mineralization, odontoblast differentiation, osteoclast maturation, phosphorylation, positive regulation of bone mineralization, positive regulation of osteoblast differentiation, post-translational protein modification, protein phosphorylation, regulation of fibroblast growth factor receptor signaling pathway, regulation of phosphorus metabolic process
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GO - Molecular function (MF):
ATP binding, calcium ion binding, manganese ion binding, phosphotransferase activity, alcohol group as acceptor, protein serine/threonine kinase activity...
ATP binding, calcium ion binding, manganese ion binding, phosphotransferase activity, alcohol group as acceptor, protein serine/threonine kinase activity
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GO - Cellular component (CC):
endoplasmic reticulum lumen, extracellular exosome, extracellular space, Golgi apparatus...
endoplasmic reticulum lumen, extracellular exosome, extracellular space, Golgi apparatus
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FAM20C golgi associated secretory pathway kinase
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Kaplan plot for FAM20C in
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*NOTE: the Kaplan plots were collected from OncoLnc