ULK2
Entrez ID: 9706
Full name: unc-51 like autophagy activating kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: ULK: ULK
Chromosomal location: 17p11.2
Substructure location: Gatekeeper: 85 A-loop: 157...179 G-loop: [N/A] αC-helix: [N/A]
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ULK2
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector an...
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
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GO - Biological processes (BP):
autophagosome assembly, autophagy, axon extension, negative regulation of collateral sprouting, positive regulation by symbiont of host autophagy, protein autophosphorylation, regulation of autophagy, response to starvation, signal transduction...
autophagosome assembly, autophagy, axon extension, negative regulation of collateral sprouting, positive regulation by symbiont of host autophagy, protein autophosphorylation, regulation of autophagy, response to starvation, signal transduction
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, cytoplasmic vesicle membrane, membrane, phagophore assembly site, phagophore assembly site membrane...
cytosol, cytoplasmic vesicle membrane, membrane, phagophore assembly site, phagophore assembly site membrane
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unc-51 like autophagy activating kinase 2
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Kaplan plot for ULK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc