MINK1
Entrez ID: 50488
Full name: misshapen like kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: MSN
Chromosomal location: 17p13.2
Substructure location: Gatekeeper: 105 A-loop: 170...193 G-loop: [N/A] αC-helix: [N/A]
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MINK1
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can ...
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
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GO - Biological processes (BP):
actin cytoskeleton reorganization, activation of protein kinase activity, chemical synaptic transmission, dendrite morphogenesis, JNK cascade, multicellular organism development, neuron projection morphogenesis, positive regulation of JNK cascade, positive regulation of p38MAPK cascade, protein auto...
actin cytoskeleton reorganization, activation of protein kinase activity, chemical synaptic transmission, dendrite morphogenesis, JNK cascade, multicellular organism development, neuron projection morphogenesis, positive regulation of JNK cascade, positive regulation of p38MAPK cascade, protein autophosphorylation, protein phosphorylation, regulation of AMPA receptor activity, regulation of cell-cell adhesion, regulation of cell-matrix adhesion, regulation of cell migration, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, extracellular exosome, Golgi apparatus, axon, cell junction, cytoplasm, dendrite, postsynaptic density...
cytosol, extracellular exosome, Golgi apparatus, axon, cell junction, cytoplasm, dendrite, postsynaptic density
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misshapen like kinase 1
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Kaplan plot for MINK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc