DCLK2
Entrez ID: 166614
Full name: doublecortin like kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: DCAMKL
Chromosomal location: 4q31.23-q31.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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DCLK2
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in...
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
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GO - Biological processes (BP):
hippocampus development, intracellular signal transduction, microtubule cytoskeleton organization, negative regulation of protein localization to nucleus, peptidyl-serine phosphorylation, pyramidal neuron development...
hippocampus development, intracellular signal transduction, microtubule cytoskeleton organization, negative regulation of protein localization to nucleus, peptidyl-serine phosphorylation, pyramidal neuron development
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
microtubule, cytoplasm...
microtubule, cytoplasm
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doublecortin like kinase 2
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Kaplan plot for DCLK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc