MLKL
Entrez ID: 197259
Full name: mixed lineage kinase domain like pseudokinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: TKL-Unique
Chromosomal location: 16q23.1
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 198...201
Please click HERE
for better display.
MLKL
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane dam...
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
View more >>
GO - Biological processes (BP):
cell surface receptor signaling pathway, necroptotic process, protein homotrimerization, protein phosphorylation...
cell surface receptor signaling pathway, necroptotic process, protein homotrimerization, protein phosphorylation
View more >>
GO - Molecular function (MF):
ATP binding, identical protein binding, protein-containing complex binding, protein kinase binding...
ATP binding, identical protein binding, protein-containing complex binding, protein kinase binding
View more >>
GO - Cellular component (CC):
cytosol, plasma membrane, cytoplasm...
cytosol, plasma membrane, cytoplasm
View more >>
mixed lineage kinase domain like pseudokinase
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for MLKL in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc