CSNK2A3
Entrez ID: 283106
Full name: casein kinase 2 alpha 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: CK2
Chromosomal location: 11p15.4
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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CSNK2A3
Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigene...
Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.
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GO - Biological processes (BP):
peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of protein catabolic process, protein phosphorylation, regulation of cell cycle...
peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of protein catabolic process, protein phosphorylation, regulation of cell cycle
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, protein kinase CK2 complex...
cytosol, nucleoplasm, nucleus, protein kinase CK2 complex
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casein kinase 2 alpha 3
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A-loop
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αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Kaplan plot for CSNK2A3 in
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*NOTE: the Kaplan plots were collected from OncoLnc