MYO3A
Entrez ID: 53904
Full name: myosin IIIA
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: NinaC
Chromosomal location: 10p12.1
Substructure location: Gatekeeper: 100 A-loop: 167...190 G-loop: [N/A] αC-helix: [N/A]
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MYO3A
Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and leng...
Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity).
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GO - Biological processes (BP):
cochlea morphogenesis, protein autophosphorylation, response to stimulus, sensory perception of sound, visual perception...
cochlea morphogenesis, protein autophosphorylation, response to stimulus, sensory perception of sound, visual perception
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GO - Molecular function (MF):
actin binding, actin-dependent ATPase activity, ADP binding, ATP binding, calmodulin binding, microfilament motor activity, plus-end directed microfilament motor activity, protein kinase activity, protein serine/threonine kinase activity...
actin binding, actin-dependent ATPase activity, ADP binding, ATP binding, calmodulin binding, microfilament motor activity, plus-end directed microfilament motor activity, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
filamentous actin, myosin complex, cytoplasm, filopodium, filopodium tip, stereocilium tip...
filamentous actin, myosin complex, cytoplasm, filopodium, filopodium tip, stereocilium tip
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myosin IIIA
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*NOTE: the Kaplan plots were collected from OncoLnc