NEK11
Entrez ID: 79858
Full name: NIMA related kinase 11
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NEK: NEK11
Chromosomal location: 3q22.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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NEK11
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation....
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
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GO - Biological processes (BP):
chromosome segregation, histone phosphorylation, intracellular signal transduction, intra-S DNA damage checkpoint, protein phosphorylation, regulation of mitotic cell cycle phase transition...
chromosome segregation, histone phosphorylation, intracellular signal transduction, intra-S DNA damage checkpoint, protein phosphorylation, regulation of mitotic cell cycle phase transition
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centrosome, nucleolus, nucleoplasm, nucleus, cytoplasm...
centrosome, nucleolus, nucleoplasm, nucleus, cytoplasm
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NIMA related kinase 11
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for NEK11 in
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*NOTE: the Kaplan plots were collected from OncoLnc