NEK9
Entrez ID: 91754
Full name: NIMA related kinase 9
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NEK: NEK9
Chromosomal location: 14q24.3
Substructure location: Gatekeeper: 128 A-loop: 193...205, 207...216 G-loop: [N/A] αC-helix: [N/A]
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NEK9
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Im...
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
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GO - Biological processes (BP):
cell division, mitotic nuclear envelope disassembly...
cell division, mitotic nuclear envelope disassembly
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein kinase binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein kinase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus...
cytosol, nucleus
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NIMA related kinase 9
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*NOTE: the Kaplan plots were collected from OncoLnc