BRSK1
Entrez ID: 84446
Full name: BR serine/threonine kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: BRSK
Chromosomal location: 19q13.42
Substructure location: Gatekeeper: 110 A-loop: 173...184, 186...195 G-loop: [N/A] αC-helix: [N/A]
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BRSK1
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, pro...
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
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GO - Biological processes (BP):
associative learning, axonogenesis, cellular response to DNA damage stimulus, centrosome duplication, establishment of cell polarity, G2/M transition of mitotic cell cycle, intracellular signal transduction, microtubule cytoskeleton organization involved in establishment of planar polarity, mitotic ...
associative learning, axonogenesis, cellular response to DNA damage stimulus, centrosome duplication, establishment of cell polarity, G2/M transition of mitotic cell cycle, intracellular signal transduction, microtubule cytoskeleton organization involved in establishment of planar polarity, mitotic G2 DNA damage checkpoint, neuron differentiation, neurotransmitter secretion, peptidyl-serine phosphorylation, protein phosphorylation, regulation of axonogenesis, regulation of neuron projection development, regulation of synaptic plasticity, regulation of synaptic vesicle clustering, response to UV, synaptic vesicle cycle
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GO - Molecular function (MF):
ATP binding, gamma-tubulin binding, magnesium ion binding, protein kinase binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity...
ATP binding, gamma-tubulin binding, magnesium ion binding, protein kinase binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity
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GO - Cellular component (CC):
centrosome, nucleoplasm, nucleus, cell junction, cytoplasm, distal axon, presynaptic active zone, synaptic vesicle...
centrosome, nucleoplasm, nucleus, cell junction, cytoplasm, distal axon, presynaptic active zone, synaptic vesicle
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BR serine/threonine kinase 1
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Kaplan plot for BRSK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc