NEK7
Entrez ID: 140609
Full name: NIMA related kinase 7
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NEK: NEK6
Chromosomal location: 1q31.3
Substructure location: Gatekeeper: 111 A-loop: 178...201 G-loop: [N/A] αC-helix: 73...87
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NEK7
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1....
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.
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GO - Biological processes (BP):
positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, protein phosphorylation, regulation of mitotic cell cycle, spindle assembly...
positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, protein phosphorylation, regulation of mitotic cell cycle, spindle assembly
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
microtubule, microtubule organizing center, spindle pole, nucleoplasm, cytoplasm...
microtubule, microtubule organizing center, spindle pole, nucleoplasm, cytoplasm
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NIMA related kinase 7
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αC-helix
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αC-helix
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Kaplan plot for NEK7 in
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*NOTE: the Kaplan plots were collected from OncoLnc