HASPIN
Entrez ID: 83903
Full name: histone H3 associated protein kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: Haspin
Chromosomal location: 17p13.2
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 491...498 αC-helix: 529...544
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HASPIN
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase al...
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
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GO - Biological processes (BP):
histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore, intracellular signal transduction, mitotic cell cycle, mitotic sister chromatid cohesion, protein localization to chromosome, centromeric region, protein phosphorylation...
histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore, intracellular signal transduction, mitotic cell cycle, mitotic sister chromatid cohesion, protein localization to chromosome, centromeric region, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, histone kinase activity (H3-T3 specific), protein kinase activity, protein serine/threonine kinase activity...
ATP binding, histone kinase activity (H3-T3 specific), protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centrosome, spindle, nucleoplasm, nucleus, chromosome, cytoplasm...
centrosome, spindle, nucleoplasm, nucleus, chromosome, cytoplasm
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histone H3 associated protein kinase
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Kaplan plot for HASPIN in
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*NOTE: the Kaplan plots were collected from OncoLnc