TTN
Entrez ID: 7273
Full name: titin
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: MLCK
Chromosomal location: 2q31.2
Substructure location: Gatekeeper: 32251 A-loop: 32317...32339 G-loop: 32184...32190 αC-helix: 32214...32228
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TTN
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determina...
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
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GO - Biological processes (BP):
actin filament organization, cardiac muscle contraction, cardiac muscle fiber development, cardiac muscle hypertrophy, cardiac muscle tissue morphogenesis, cardiac myofibril assembly, detection of muscle stretch, mitotic chromosome condensation, muscle contraction, muscle filament sliding, platelet ...
actin filament organization, cardiac muscle contraction, cardiac muscle fiber development, cardiac muscle hypertrophy, cardiac muscle tissue morphogenesis, cardiac myofibril assembly, detection of muscle stretch, mitotic chromosome condensation, muscle contraction, muscle filament sliding, platelet degranulation, positive regulation of gene expression, positive regulation of protein secretion, protein kinase A signaling, regulation of catalytic activity, regulation of protein kinase activity, response to calcium ion, sarcomere organization, sarcomerogenesis, skeletal muscle myosin thick filament assembly, skeletal muscle thin filament assembly, striated muscle contraction, striated muscle myosin thick filament assembly
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GO - Molecular function (MF):
actin filament binding, actinin binding, ATP binding, calcium ion binding, calmodulin binding, enzyme binding, identical protein binding, muscle alpha-actinin binding, protease binding, protein kinase binding, protein self-association, protein serine/threonine kinase activity, protein tyrosine kinas...
actin filament binding, actinin binding, ATP binding, calcium ion binding, calmodulin binding, enzyme binding, identical protein binding, muscle alpha-actinin binding, protease binding, protein kinase binding, protein self-association, protein serine/threonine kinase activity, protein tyrosine kinase activity, structural constituent of muscle, structural molecule activity conferring elasticity, telethonin binding
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GO - Cellular component (CC):
striated muscle thin filament, cytosol, extracellular exosome, extracellular region, condensed nuclear chromosome, I band, M band, sarcomere, Z disc...
striated muscle thin filament, cytosol, extracellular exosome, extracellular region, condensed nuclear chromosome, I band, M band, sarcomere, Z disc
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titin
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*NOTE: the Kaplan plots were collected from OncoLnc