DYRK2
Entrez ID: 8445
Full name: dual specificity tyrosine phosphorylation regulated kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: DYRK: DYRK2
Chromosomal location: 12q15
Substructure location: Gatekeeper: 301 A-loop: 367...387 G-loop: 229...236 αC-helix: 257...274
Please click HERE
for better display.
DYRK2
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphor...
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
View more >>
GO - Biological processes (BP):
cellular response to DNA damage stimulus, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of calcineurin-NFAT signaling cascade, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of glycogen biosyntheti...
cellular response to DNA damage stimulus, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of calcineurin-NFAT signaling cascade, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of glycogen biosynthetic process, protein phosphorylation, regulation of signal transduction by p53 class mediator, smoothened signaling pathway
View more >>
GO - Molecular function (MF):
ATP binding, magnesium ion binding, manganese ion binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, magnesium ion binding, manganese ion binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity
View more >>
GO - Cellular component (CC):
cytoskeleton, cytosol, nucleoplasm, nucleus, cytoplasm, ribonucleoprotein complex, ubiquitin ligase complex...
cytoskeleton, cytosol, nucleoplasm, nucleus, cytoplasm, ribonucleoprotein complex, ubiquitin ligase complex
View more >>
dual specificity tyrosine phosphorylation regulated kinase 2
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for DYRK2 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc