MAP4K1
Entrez ID: 11184
Full name: mitogen-activated protein kinase kinase kinase kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: KHS
Chromosomal location: 19q13.2
Substructure location: Gatekeeper: 91 A-loop: 154...165, 168...177 G-loop: [N/A] αC-helix: [N/A]
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MAP4K1
Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able t...
Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity).
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GO - Biological processes (BP):
activation of JUN kinase activity, activation of MAPKKK activity, activation of protein kinase activity, cell population proliferation, cellular response to phorbol 13-acetate 12-myristate, MAPK cascade, peptidyl-serine phosphorylation, protein autophosphorylation, protein phosphorylation, regulatio...
activation of JUN kinase activity, activation of MAPKKK activity, activation of protein kinase activity, cell population proliferation, cellular response to phorbol 13-acetate 12-myristate, MAPK cascade, peptidyl-serine phosphorylation, protein autophosphorylation, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase kinase kinase activity, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, MAP kinase kinase kinase kinase activity, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytoplasm, membrane...
cytoplasm, membrane
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mitogen-activated protein kinase kinase kinase kinase 1
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Kaplan plot for MAP4K1 in
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*NOTE: the Kaplan plots were collected from OncoLnc