SGK3
Entrez ID: 23678
Full name: serum/glucocorticoid regulated kinase family member 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: SGK
Chromosomal location: 8q13.1
Substructure location: Gatekeeper: 240 A-loop: 303...326 G-loop: [N/A] αC-helix: [N/A]
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SGK3
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ c...
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
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GO - Biological processes (BP):
intracellular signal transduction, ion transmembrane transport, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, peptidyl-serine phosphorylation, protein phosphorylation, regulation of cell growth, regulation of cell migration, regulation of cell population prolifer...
intracellular signal transduction, ion transmembrane transport, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, peptidyl-serine phosphorylation, protein phosphorylation, regulation of cell growth, regulation of cell migration, regulation of cell population proliferation, regulation of DNA-binding transcription factor activity
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GO - Molecular function (MF):
ATP binding, calcium channel regulator activity, chloride channel regulator activity, phosphatidylinositol binding, potassium channel regulator activity, protein kinase activity, protein serine/threonine kinase activity, sodium channel regulator activity...
ATP binding, calcium channel regulator activity, chloride channel regulator activity, phosphatidylinositol binding, potassium channel regulator activity, protein kinase activity, protein serine/threonine kinase activity, sodium channel regulator activity
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GO - Cellular component (CC):
cytosol, early endosome, recycling endosome, nucleoplasm, intracellular membrane-bounded organelle...
cytosol, early endosome, recycling endosome, nucleoplasm, intracellular membrane-bounded organelle
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serum/glucocorticoid regulated kinase family member 3
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Kaplan plot for SGK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc