COQ8B
Entrez ID: 79934
Full name: coenzyme Q8B
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: ABC1: ABC1-A
Chromosomal location: 19q13.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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COQ8B
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule ki...
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420).
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GO - Biological processes (BP):
cerebellar Purkinje cell layer morphogenesis, protein phosphorylation, ubiquinone biosynthetic process...
cerebellar Purkinje cell layer morphogenesis, protein phosphorylation, ubiquinone biosynthetic process
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GO - Molecular function (MF):
ATP binding, kinase activity...
ATP binding, kinase activity
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GO - Cellular component (CC):
cytosol, extrinsic component of mitochondrial inner membrane, mitochondrion, plasma membrane, integral component of membrane...
cytosol, extrinsic component of mitochondrial inner membrane, mitochondrion, plasma membrane, integral component of membrane
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coenzyme Q8B
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 10 samples
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Kaplan plot for COQ8B in
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*NOTE: the Kaplan plots were collected from OncoLnc