AURKB
Entrez ID: 9212
Full name: aurora kinase B
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: Aur
Chromosomal location: 17p13.1
Substructure location: Gatekeeper: 154 A-loop: [N/A] G-loop: 80...91 αC-helix: 110...116
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AURKB
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubul...
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
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GO - Biological processes (BP):
abscission, aging, anaphase-promoting complex-dependent catabolic process, attachment of spindle microtubules to kinetochore, cell population proliferation, cellular response to UV, cleavage furrow formation, histone H3-S28 phosphorylation, histone modification, mitotic cytokinesis checkpoint, mitot...
abscission, aging, anaphase-promoting complex-dependent catabolic process, attachment of spindle microtubules to kinetochore, cell population proliferation, cellular response to UV, cleavage furrow formation, histone H3-S28 phosphorylation, histone modification, mitotic cytokinesis checkpoint, mitotic spindle assembly checkpoint, mitotic spindle midzone assembly, mitotic spindle organization, negative regulation of B cell apoptotic process, negative regulation of cytokinesis, negative regulation of protein binding, negative regulation of transcription by RNA polymerase II, positive regulation of cytokinesis, positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore, positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, protein autophosphorylation, protein localization to kinetochore, protein phosphorylation, regulation of chromosome segregation, regulation of cytokinesis, regulation of signal transduction by p53 class mediator, spindle organization, ubiquitin-dependent protein catabolic process
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GO - Molecular function (MF):
ATP binding, histone serine kinase activity, kinase binding, metal ion binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity...
ATP binding, histone serine kinase activity, kinase binding, metal ion binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
chromosome passenger complex, mitotic spindle midzone, spindle, spindle microtubule, spindle midzone, spindle pole centrosome, cytosol, condensed nuclear chromosome, centromeric region, nucleoplasm, nucleus, chromocenter, condensed chromosome, centromeric region, kinetochore, midbody...
chromosome passenger complex, mitotic spindle midzone, spindle, spindle microtubule, spindle midzone, spindle pole centrosome, cytosol, condensed nuclear chromosome, centromeric region, nucleoplasm, nucleus, chromocenter, condensed chromosome, centromeric region, kinetochore, midbody
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aurora kinase B
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Kaplan plot for AURKB in
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*NOTE: the Kaplan plots were collected from OncoLnc